At the regional and continental level, Dr. Kikwete held various regional leadership positions as Chair of South African Development Community (SADC), Chair of the East African Community (EAC) and Chair of the African Union. He has also participated and contributed in many peace initiatives as Chair of the International Conference on the Great Lakes Region, Burundi Peace Process and Member of the AU High Level Committee on Ivory Coast Political Crisis to name but a few.

Internationally, Dr. Kikwete has served as Co-Chair of the African Commission on Youth, Co-Chair of the Helsinki Process on Globalization and Democracy; the Co-Chair of the UN Commission of Information and Accountability on Women’s and Children’s Health; Chairperson of the United Nations High Level Panel on the Global Response to Health Crisis; and Chairperson of the African Leaders Malaria Alliance (ALMA).